AFE Action
Clinicians are Key to Helping Us #ENDAFE

Clinician Engagement Toolkit

Raise AFE Awareness

Step Up Your Game Against AFE!

Champions in maternal health don’t sit on the sidelines—they take action. It’s time to rally, refine your skills, and execute the best plays against AFE.

Take the Shot: Enroll in our AFE Course
Run the Drills: Implement our AFE Simulation Toolkit
Review the Play: Submit a Case
Lead the Team: Invite Us to Speak

Together, we can outplay AFE and bring hope to families worldwide. Are you in?

AFE Awareness Day joins the affected community and health care providers to raise awareness, honor their connection to the cause, and inspire meaningful action.

What is an Amniotic Fluid Embolism?

An amniotic fluid embolism (AFE) is an obstetric emergency characterized by acute hypotension, hypoxia, and coagulopathy. It is thought to be a result of an anaphylactic-like reaction to amniotic fluid or fetal components in the maternal circulation, a normally benign result of the birthing process. Although rare, it is often-fatal and remains a leading cause of maternal morbidity and mortality in the United States. It may also be referred to as anaphylactoid syndrome of pregnancy. Why Raise Awareness? AFE is a rare and catastrophic event affecting 1 in 40,000 pregnancies with nearly 40% experiencing a cardiac arrest as the first symptom. Most healthcare staff who encounter a patient with AFE will likely have no actual AFE patient care experience and limited practice in how to respond. Raising AFE awareness is crucial for early recognition and prompt intervention to improve outcomes for mothers and babies.

Why Raise Awareness?

AFE is a rare and catastrophic event affecting 1 in 40,000 pregnancies with nearly 40% experiencing a cardiac arrest as the first symptom. Most healthcare staff who encounter a patient with AFE will likely have no actual AFE patient care experience and limited practice in how to respond. Raising AFE awareness is crucial for early recognition and prompt intervention to improve outcomes for mothers and babies.

Key Messages

AFE is characterized by sudden hypotension, hypoxia, and disseminated intravascular coagulopathy.
AFE is estimated to affect 1 in 40,000 pregnancies.
AFE remains poorly understood but is thought to involve a severe immune response to amniotic fluid in the maternal circulation.
Treatment is entirely supportive.
AFE is a clinical diagnosis of exclusion.
Clinicians, patients or family members are encouraged to submit cases to the AFE Registry.
Specimens taken before and during an AFE are needed for clinical research.